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KMID : 0358320060470010047
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Korean Journal of Urology
2006 Volume.47 No. 1 p.47 ~ p.54
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The Effect of Botulinum Toxin and Resiniferatoxin on the Detrusor Overactivity Induced by Cyclophosphamide in Rat Bladder
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Kim San-Wook
Shim Kang-Soo
Lee Jeong-Gu
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Abstract
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Purpose: The purpose of this study was to compare the effects of resiniferatoxin(RTX) and botulinum toxin(BTX) on the bladder detrusor function in a cyclophosphamide(CYP)-induced cystitis rat model.
Materials and Methods: Sprague-Dawley rats were divided into 5 groups (1: saline treated, 2: CYP and BTX treated, 3: CYP and RTX treated, 4 and 5: CYP treated and sham operated as the counterpart of groups 2 and 3, respectively, with normal saline). 100mg/kg CYP was injected every third day for five weeks. Cystometrograms were performed after the BTX and RTX treatments.
Results: 1. The normal control group and the CYP-treated only group. In the CYP-treated group, the time of micturition frequency, the maximal detrusor pressure on the cystometergram(Pvesmax at CMG), the maximal detrusor pressure on the pressure-flow study(Pvesmax at pr/flow) and the episodes of irregular contractions were increased. 2. The CYP-only group and the CYP/BTX or CYP/RTXtreated groups. In the CYP/BTX or CYP/RTX treated groups, the time of micturition frequency, the Pvesmax at CMG, the Pvesmax at pr/flow and the episode of irregular contractions were decreased. 3. The CYP/BTXtreated group and the CYP/ RTXtreated group. There was no statistically significant difference between the two groups regarding micturition frequency, the PvesMax at CMG and the PvesMax at pr/flow, the Dhfo and the episodes of involuntary contractions(p＞0.05).
Conclusions: Intravesical administration of BTX or RTX blocked the CYP-induced detrusor overactivity as was shown by the restoration of the micturition frequency, the intravesical pressure and the involuntary contraction episodes to a control level. There was no statistically significant difference between the two groups regarding the urodynamic parameters. (Korean J Urol 2006;47:47-54)
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KEYWORD
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Botulinum toxins, Resiniferatoxin, Cyclophosphamide
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